![]() ![]() ![]() A comprehensive view of such relationships may mitigate nonspecific therapeutic targeting of the whole kidney and entire cellular communities, and pave the way for better, more precise drugs with fewer side effects. They also performed spatial analyses to create 3D pictures of cells living in communities and communicating with their neighbors. Using single-cell analyses, the researchers characterized the molecular features of healthy and diseased kidney cells in different kidney segments from patient kidney biopsy samples. Treatment options are limited to dialysis or difficult-to-come-by organ donation. Chronic illnesses such as diabetes and hypertension and accumulating kidney injury – through physiological aging, low oxygen or changes in blood flow to the kidneys during surgery, reactions to medication, recreational drug use and even dehydration – can rapidly accelerate natural decline and cause kidney disease and, ultimately, kidney failure. Kidney functional mass slowly declines after age 35. Jain is also a co-senior author on another of the studies, published in Nature Communications, that maps healthy and injured cellular neighborhoods in areas where kidney stones form, and identifies biomarkers in the urine that are unique to patients with kidney stone disease. The new research is one of nine studies, published simultaneously across the Nature Portfolio journals, introducing the first set of maps created by researchers at institutions supported by HuBMAP. The study also received support from HuBMAP, an NIH Common Fund-sponsored program that aims to spatially define every cell in the healthy human body, and the Human Cell Atlas, an international research effort to gather information on at least 10 billion human cells. It is working to do so with the help of participants with kidney disease who are willing to undergo kidney biopsies solely to contribute to research. ![]() The Kidney Precision Medicine Project, also supported by the NIH, aims to improve kidney disease treatment. Kim, MD, an associate professor of surgery, worked with other members of the Kidney Precision Medicine Project (KPMP), Human BioMolecular Atlas Program (HuBMAP), Human Cell Atlas, and scientists from other institutions to complete single-cell and spatial tests on nearly 100 healthy and diseased human kidneys. Gaut, MD, PhD, the Ladenson Professor of Pathology & Immunology Anitha Vijayan, MD, a professor of medicine in the Division of Nephrology and Eric H. Jain’s team, including co-investigators Joseph P. This molecular knowledge will, one day, lead us to precise, customized treatments for our patients.” “By mapping molecular signatures, we hope to predict which patients are at risk of progressing to kidney failure. “We don’t have great treatment options for patients with kidney disease,” said Sanjay Jain, MD, PhD, a Washington University professor of medicine who led this study with five co-corresponding authors. The study, funded by the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health (NIH), is published July 19 in Nature. Altogether, they created a comprehensive 2D and 3D map of kidney cell organization and molecular identity in healthy and diseased kidneys. They uncovered diverse cellular microcosms with rich genetic signatures along segments of the kidney associated with kidney failure in patients or recovery from injury. ![]() The aim of the kidney tissue atlas is to further the understanding of kidney injury and disease.īuilding on previous work showing 30 cell types in the kidney, the researchers revealed 51 cell types, some rare and novel, in the healthy kidney and 28 related cell types with features associated with injury or recovery. Louis are among the leaders of a multi-institution research team that has built an atlas focused on the kidney’s myriad cells. Scientists at Washington University School of Medicine in St. Louis helped lead a major study, funded by the National Institutes of Health (NIH), that uncovered rich cellular and molecular diversity in healthy and diseased kidneys, creating a kidney tissue atlas that will help further understanding of kidney injury and disease. Researchers at Washington University School of Medicine in St. Research collaboration details molecular knowledge, step toward personalized medicine News Release Kidney tissue atlas serves as blueprint for understanding kidney injury, disease ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |